Hemoglobin Replacement Device Treatment of Sickle Cell Disease

Sickle Cell Disease, also known as hemoglobinopathy, is a genetic defect resulting in abnormal structure of the hemoglobin molecules. Abnormally shaped RBCs cause gradual, eventually fatal damage to all organs. Transfusion of normal RBCs prolongs life, but repeated transfusion leads to alloimmunization. The team is developing a hemoglobin replacement device that would replace the patient’s abnormal hemoglobin with donor hemoglobin, preventing alloimmunization and improving the disease treatment.